Dopamin hypothese

Die Dopaminhypothese geht davon aus, dass abnorme Dopaminwerte im Gehirn zu psychotischen Realitätsverkennungen führen. Dies begründet sich mit verfälschten. 1 Die Dopaminhypothese der Schizophrenien – kurz Dopaminhypothese – ist die Hypothese vom Zusammenhang zwischen dem Neurotransmitter Dopamin und den psychotischen Krankheitsbildern der Schizophrenien. 2 FeedbackErklärungsansatz zur Entstehung einer Schizophrenie, bei dem ein Überangebot an Dopamin in mesolimbischen Strukturen Positivsymptome auslösen soll. 3 Die Dopaminhypothese der Schizophrenien gründet sich auf die Beobachtung der neu- roleptikabedingten Blockade zentraler Dop- amin-D2-Rezeptoren. 4 Dopamine hypothesis. The dopamine hypothesis of ADHD is based on the facts: (1) that symptoms of ADHD are reduced by stimulant treatment which blocks the dopamine reuptake mechanism in the striatum; and (2) that some patients with ADHD have abnormalities in genes responsible for dopamine regulation. However, this hypothesis has been questioned. 5 Bipolar affective disorder is a common neuropsychiatric disorder. Although its neurobiological underpinnings are incompletely understood, the dopamine hypothesis has been a key theory of the pathophysiology of both manic and depressive phases of the illness for over four decades. The increased use o . 6 The dopamine hypothesis of schizophrenia is based on a wide variety of circumstantial evidence, as follows: 1. High doses of dopamine-mimetics elicit hallucinations (Angrist et al., ; Snyder, ). 2. Neuroleptics accelerate the turnover of brain dopamine (Da Prada and Pletscher, ; Rollema et al., ). 3. 7 The dopamine hypothesis of schizophrenia or the dopamine hypothesis of psychosis is a model that attributes the positive symptoms of schizophrenia to a disturbed and hyperactive dopaminergic signal transduction. The model draws evidence from the observation that a large number of antipsychotics have dopamine- receptor antagonistic effects. 8 The dopamine hypothesis stems from early research carried out in the ’s and ’s when studies involved the use of amphetamine (increases dopamine levels) which increased psychotic symptoms while reserpine which depletes dopamine levels reduced psychotic symptoms. The original dopamine hypothesis was put forward by Van Rossum in 9 The dopamine hypothesis of schizophrenia has been one of the most enduring ideas in psychiatry. Initially, the emphasis was on a role of hyperdopaminergia in the etiology of schizophrenia (version I), but it was subsequently reconceptualized to specify subcortical hyperdopaminergia with prefrontal hypodopaminergia (version II). dopaminhypothese depression 10 Es gibt zunehmend Hinweise. 11 schizophrenie dopaminüberschuss 12